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@Red.Rooster I wish you the best in your search for a cure to your wife’s ailment!
My boy has a severe peanut allergy (life threatening - holy crap it’s scary). Because of his allergy he is sensitive to many things. We make our own laundry detergent, watch all ingredients of food, and make our own sun screen. His skin is too sensitive for over the counter stuff.
What @KUSTEVE suggested is a great idea. Get out of the house for more than 3 consecutive days to see if there’s a trigger at home. This would be the best way to eliminate your house and many things associated with it. However, you will be bringing things from home - clothes, toiletries, etc. If things don’t clear up then they must be eliminated too. As well as bringing in new possible triggers- hotel’s detergent, ventilation, etc.
One other thing, I had a friend who was “allergic” to the sun and sunlight exposure would leave him with itchy skin, but not under his clothes. - Doesn’t sound like your wifes issue, but I though I’d throw it out there.
I have a couple of family members with MS, that would be my fear. Usually it feels like you are on fire as the coating covering the nerves breaks down. There are medicines to help mitigate the disease.
I hope you find a good outcome to your wife’s ailment. Don’t be afraid to lean on others in your time of need. It is just as helpful for them to allow them to help as it is to you.